Work

Targeting Epigenetics in Lung Cancer

Year: 2020

Type: preprint

Abstract: The epigenetic landscape, which in part includes DNA methylation, chromatin organization, histone modifications, and noncoding RNA regulation, greatly contributes to the heterogeneity that makes developing effective therapies for lung cancer challenging. This review will provide an overview of the epigenetic alterations that have been implicated in all aspects of cancer pathogenesis and progression as well as summarize clinical applications for targeting epigenetics in the treatment of lung cancer.

Source: Cold Spring Harbor Perspectives in Medicine

DOI: 10.1101/cshperspect.a038000

Authors: Yvonne L. Chao, Chad V. Pecot

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute