Year: 2020
Type: article
Abstract: Fridericia speciosa (Bignoniaceae) is a liana that occurs in humid to dry vegetation in eastern and southeastern Brazil.Species belonging to the genus Fridericia are employed as medicinal plants.This study evaluates the antipromastigote and cytotoxic activities of the crude extract, fractions, and compounds isolated from F. speciosa, and an HPLC (High-Performance Liquid Chromatography) analytical method was used to quantify the bioactive flavonoids.The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated from the active EtOAc-soluble fraction (EAF) of the crude ethanol extract (LCE) obtained from F. speciosa leaves.Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC 50 of 460.7 μg mL -1 and 381.4 μg mL -1 , respectively).Only EAF showed activity against Leishmania amazonensis (80.4% at 50 μg mL -1 ).Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%).At 100 μM, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively, while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 μg mL -1 , respectively.Therefore, F. speciosa leaves are a prolific source of bioactive flavonoids.
Source: Química Nova
Institution: Universidade de Franca
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $330
OpenAlex ID: W3084406821