Work

Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone

Year: 2020

Type: article

Abstract: Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (Q) fever. During natural infection of female animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, at which time the pathogen titer in placental tissue can exceed one billion bacteria per gram. During later stages of pregnancy, placental trophoblasts serve as the major source of progesterone, a steroid hormone known to affect the replication of some pathogens.

Source: Infection and Immunity

DOI: 10.1128/iai.00894-19

Authors: Zachary P. Howard, Anders Omsland

Institution: Washington State University

Language: English

Topic: Vector-borne infectious diseases

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Washington State University, National Institutes of Health, National Institute of Allergy and Infectious Diseases