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Does depression increase the risk of dementia? Updated meta-analysis of prospective studies.

Year: 2020

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: BACKGROUND: Our primary aim was to conduct an update meta-analysis of prospective studies investigating the association between depression and dementia risk. METHODS: We searched Pubmed database to identify all relevant papers published from January 2014 to March 2019. Prospective studies with a minimum follow-up period of 1 year, baseline depression assessment, absence of dementia or mild cognitive impairment at baseline were selected. We calculated pooled relative risks (RR), with a random effect model, as well as compute population attributable fraction (PAF) of dementia due to depression. RESULTS: Eight cohorts were included. A statistically significant association between depression and dementia risk, with a pooled RR of 1.63 (95% CI: 1.30-2.04), and a PAF of 9.0% (95% CI: 4.5%-14.1%), were found. CONCLUSIONS: Depression is associated with an increased risk of dementia in this meta-analysis.

Source: Actas Españolas de Psiquiatría

Authors: Javier Santabárbara, Beatriz Villagrasa, Patricia Gracia-García

Institutions: Universidad de Zaragoza, Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3085159802

FWCI: 0.867

Cites:

Cited by: 10

Related to: 10