Vitamin D intake is associated with dementia risk in the Washington Heights‐Inwood Columbia Aging Project (WHICAP)
Year: 2020
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Low vitamin D intake and low vitamin D circulating levels have been associated with increased risk for dementia. We aimed to examine the association between vitamin D intake and dementia in a multiethnic cohort. METHODS: A longitudinal study of 1759 non-demented older (≥65 years) participants of the Washington Heights-Inwood Columbia Aging Project with follow-up visits and completed a food frequency questionnaire. Dementia was diagnosed by consensus using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. Cox hazard regression was performed. RESULTS: During a mean follow-up of 5.8 years, 329 participants developed dementia. Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54-0.97, P = .030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-ε4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking. DISCUSSION: Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12096
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1133076894, G1827772993, G1878018945, Epidemiology of Biomarkers of Risk and Progression in LOAD, Epidemiology of Dementia In An Urban Community, G3741245994, Neuroepidemiology Training Program, The role of inflammation in the association between diet and Alzheimer's disease, Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's Disease, G5640479584, G6488371260
OpenAlex ID: W3085285813