Work

Targeting hepcidin improves cognitive impairment and reduces iron deposition in a diabetic rat model.

Year: 2020

Type: article

Abstract: = 0.002). MWM results showed that the performance of T2DM rats was significantly decreased from that of control rats. Compared with the M-saline and M-blank groups, the performance of the M-hepcidin group was significantly increased. These studies demonstrate that T2DM rats developed cognitive impairment and iron deposits in the hippocampus, both of which were improved by AAV-hepcidin administration.

Source: PubMed Central

Authors: Juan Liu, Xiaofei Hu, Yuan Xue, Chen Liu, Daihong Liu, Yongning Shang, Yanshu Shi, Lin Cheng, Jiqiang Zhang, Antao Chen, Jian Wang

Institutions: Southwest University, Army Medical University, Southwest Hospital, Chongqing University, Chongqing Cancer Hospital

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3085677602

FWCI: 1.105

Cites: 33

Cited by: 10

Related to: 10