α-Syn oligomers incubated with Parkinson's disease plasma promote neuron damage.
Year: 2020
Type: article
Abstract: , o-α-Syn-PD significantly reduced dopaminergic neurons in the substantia nigra and could be transferred to the cortex, hippocampus, and other parts of the brain. Mice administered o-α-Syn-PD exhibited significant PD-like dyskinesia changes in a short period of time. Finally, o-α-Syn-PD injection was associated with decreased GCase and PP2A activities in the mouse brain. The above findings provide novel insights into the effect of o-α-Syn on neurodegeneration in PD and dementia with LBs.
Source: PubMed
Authors: Weiwei Yang, Xuran Li, Na Yin
Institution: Xuan Wu Hospital of the Capital Medical University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3086002901