Work

The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study

Year: 2020

Type: article

Abstract: BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women. RESULTS: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed. CONCLUSION: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2020.540724

Authors: Su Yon Jung, Nicholas Mancuso, Sihao Han, Zuo-Feng Zhang

Institutions: University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center, University of Southern California, USC Norris Comprehensive Cancer Center

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950