A DNA quantitative analysis of lung cancer cells with different pathological types from bronchial brush specimens and its clinical significance.
Year: 2020
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To explore the significance of a DNA quantitative analysis of lung cancer cells with different pathological types taken from bronchial brush specimens and its relationship with the clinicopathological features. METHODS: 903 bronchial brush cytological specimens taken in the Cytology Department of the Fourth Hospital of Hebei Medical University were collected from March 2017 to December 2019 and divided into three groups: the squamous carcinoma (SC) group, the adenocarcinoma (AC) group, and the small-cell carcinoma (SCC) group. The maximum DNA index (DI) value, the percentage of cells with a DI larger than 2.5, the mean DI, and the peaks of the aneuploid cells of the three groups were compared. A single factor analysis was used to analyze the relationship between the DNA content, aneuploidy, and the clinico pathological features of the patients who had surgery. RESULTS: > 0.05). CONCLUSION: The reason why the DNA content of small-cell lung cancer is lower than SC and AC remains to be further studied.
Source: PubMed
Institution: Fourth Hospital of Hebei Medical University
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3086321585