Work

Kinetic differences between macro- and microvascular measures of reactive hyperemia

Year: 2020

Type: article

Abstract: We extend our understanding of macro- versus microvascular hemodynamics in humans, by using near-infrared diffuse correlation spectroscopy (micro-) and Doppler ultrasound (macro-) to characterize reperfusion hemodynamics following experimental manipulation of the ischemic stimulus and tissue perfusion pressure. Our results suggest kinetic differences between macro- and microvascular reperfusion are largely determined by differences in fluid mechanical energy (i.e., pressure, gravitational, and kinetic energies) between the two compartments, rather than inherent differences between the macro- and microvasculature.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00481.2020

Authors: Miles F. Bartlett, Andrew Oneglia, Manall Jaffery, Shayla Manitowabi-Huebner, Dennis M. Hueber, Michael D. Nelson

Institutions: The University of Texas at Arlington, International Space Station

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute