Work

Design and synthesis of a bis-macrocyclic host and guests as building blocks for small molecular knots

Year: 2020

Type: article

Abstract: The thread-link-cut (TLC) approach has previously shown promise as a novel method to synthesize molecular knots. The modular second-generation approach to small trefoil knots described herein involves electrostatic interactions between an electron-rich bis-macrocyclic host compound and electron-deficient guests in the threading step. The bis-macrocyclic host was synthesized in eight steps and 6.6% overall yield. Ammonium and pyridinium guests were synthesized in 4-5 steps. The TLC knot-forming sequence was carried out and produced a product with the expected molecular weight, but, unfortunately, further characterization did not produce conclusive results regarding the topology of the product.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.16.192

Authors: Elizabeth A Margolis, Rebecca J Keyes, Stephen D Lockey, Edward E Fenlon

Institution: Franklin & Marshall College

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W3087448747

FWCI:

Cites: 29

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Related to: 10