Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations
Year: 2020
Type: article
Abstract: H-MRS provides an effective means to measure low-concentration metabolite signals that cannot be reliably measured by conventional MRS techniques due to signal overlap, for example, γ-aminobutyric acid, glutathione and D-2-hydroxyglutarate. Spectral editing strategies utilize known J-coupling relationships within the metabolite of interest to discriminate their resonances from overlying signals. This consensus recommendation paper provides a brief overview of commonly used homonuclear editing techniques and considerations for data acquisition, processing and quantification. Also, we have listed the experts' recommendations for minimum requirements to achieve adequate spectral editing and reliable quantification. These include selecting the right editing sequence, dealing with frequency drift, handling unwanted coedited resonances, spectral fitting of edited spectra, setting up multicenter clinical trials and recommending sequence parameters to be reported in publications.
Source: NMR in Biomedicine
DOI: 10.1002/nbm.4411
Institutions: University of Kansas Medical Center, Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Kennedy Krieger Institute, Johns Hopkins University, Johns Hopkins Medicine, Medical University of Vienna, University of California, Berkeley, University of Minnesota, Yale University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Institut National de la Santé et de la Recherche Médicale, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences
Awards: G1044130170, G1140538806, G1257310684, G1313834744, G1420189321, G1698840832, G2071353191, Intellectual and Developmental Disabilities Research Centers 2020, G3319793785, Resource for Quantitative Functional FMRI, G458629407, G5581224793, G6348047465, Institutional Center Cores for Advanced Neuroimaging, G7439152590, G7448275283, G7483825711, Antioxidant Imaging Marker of Investigating Gains in Neurocognition in an Intervention Trial of Exercise (AIM-IGNITE), G8183162605, G8414666878, Technology to Realize the Full Potential of UHF MRI, Development of multinuclear MRI for image guided therapy of glioma patients, Targeted Therapies for Glioma, Yale Clinical and Translational Science Award, Universal Edited MRS at 3T
OpenAlex ID: W3087491240