Work

Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders

Year: 2020

Type: article

Abstract: Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD-GRS score was associated with shorter sleep (b = -0.014, 95% confidence interval [CI] = -0.022 to -0.006), especially in those aged 55+. Using AD-GRS as an instrumental variable for AD diagnosis, incipient AD reduced sleep duration by 1.87 hours (95% CI = 0.96, 2.78). Short sleep duration might be an early marker of AD. ANN NEUROL 2021;89:177-181.

Source: Annals of Neurology

DOI: 10.1002/ana.25910

Authors: Yue Leng, Sarah F. Ackley, Maria M. Glymour, Kristine Yaffe, Willa D. Brenowitz

Institutions: University of California, San Francisco, San Francisco VA Medical Center, San Francisco VA Health Care System

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging