The Cystic Fibrosis Transmembrane Conductance Regulator as a Potential Link Between the Circadian Clock and the Myogenic Response
Year: 2018
Type: dissertation
Abstract: Cerebral autoregulation maintains relatively constant cerebral perfusion despite variations in mean arterial pressure (MAP), mainly through the myogenic response: the intrinsic ability of cerebral resistance arteries to adapt their tone to transmural pressure. I demonstrate that the myogenic responsiveness of these arteries exhibits a circadian rhythm which is anti-phasic with that of the cremaster skeletal muscle arteries. This rhythm in cerebral artery myogenic responsiveness provides a functional basis to cope with circadian oscillations in MAP. Both mRNA and protein expression of the cystic fibrosis transmembrane conductance regulator (CFTR) oscillate in a fashion that is consistent with its role as a negative regulator of the myogenic response, and circadian rhythmicity in CFTR mRNA expression persists under constant darkness. Our data suggest that rhythmic expression of CFTR may be responsible for the functional phenotype.
Source: TSpace (University of Toronto)
Author: Chloe Ng
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3087580643