Work

The von Hippel-Lindau Tumor Suppressor Gene

Year: 2020

Type: article

Abstract: The discovery of the von Hippel-Lindau (VHL) gene marked a milestone in our understanding of clear cell renal cell carcinoma (ccRCC) pathogenesis. VHL inactivation is not only a defining feature of ccRCC, but also the initiating event. Herein, we discuss canonical and noncanonical pVHL functions, as well as breakthroughs shaping our understanding of ccRCC evolution and evolutionary subtypes. We conclude by presenting evolving strategies to therapeutically exploit effector mechanisms downstream of pVHL.

Source: The Cancer Journal

DOI: 10.1097/ppo.0000000000000480

Authors: Roy Elias, Qing Zhang, James Brugarolas

Institutions: Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute