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Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Year: 2020
Type: review
Abstract: Protein-protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a direction in treating diseases and an essential strategy for the development of new drugs. In the past few decades, the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks. In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small molecules, peptides, and antibodies, hoping to provide some guidance to the design of novel drugs targeting PPIs in the future.
DOI: 10.1038/s41392-020-00315-3
Authors: Haiying Lu, Qiaodan Zhou, Jun He, Zhongliang Jiang, Cheng Peng, Rongsheng Tong, Jianyou Shi
Institutions: University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan University, West China Medical Center of Sichuan University, University of Miami, Chengdu University of Traditional Chinese Medicine
Language: English
Open Access status: gold
Estimated APC paid: $2,680
Funders: Department of Science and Technology of Sichuan Province, State Administration of Traditional Chinese Medicine of the People's Republic of China, Chengdu University of Traditional Chinese Medicine, Chengdu Science and Technology Bureau, Chengdu University, Chengdu Science and Technology Program
OpenAlex ID: W3087769169
FWCI: 8.842
Cites: 272
Cited by: 891
Related to: 10