Work

Cadherin-based biomaterials: Inducing stem cell fate towards tissue construction and therapeutics

Year: 2020

Type: article

Abstract: The precise regulation of cell fate by biomaterials is one of the core focuses in tissue engineering and regenerative therapeutics. Cell fate is controlled by the niche signaling cues, including growth factors/morphogens, direct cell-cell contact, and extracellular matrix components. Here, we discuss how to bio-mimic cell-cell interaction by tailoring the interface of biomaterials to design effective scaffolds. Cadherins, as a key cell membrane protein family mediating the intercellular adherens junction, have attracted extensive attention in the functional modification of biomaterials. Therefore, cadherin-based biomaterials, their ability to modulate stem cell fate, and their applications in regenerative medicine are reviewed. Furthermore, we provide an outlook for exploiting the bio-mimic biomaterials in advanced cell therapeutics.

Source: Progress in Natural Science Materials International

DOI: 10.1016/j.pnsc.2020.09.001

Authors: Yan Zhang, Zheng Qin, Zhanyuan Qu, Min Ge, Jun Yang

Institutions: Nankai University, State Key Laboratory of Medicinal Chemical Biology

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,790