Work

Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales

Year: 2020

Type: article

Abstract: Several fatal bunyavirus infections lack specific treatment. Here, we show that diketo acids engage a panel of bunyavirus cap-snatching endonucleases, inhibit their catalytic activity and reduce viral replication of a taxonomic representative in vitro. Specifically, the non-salt form of L-742,001 and its derivatives exhibited EC50 values between 5.6 and 6.9 μM against a recombinant BUNV-mCherry virus. Structural analysis and molecular docking simulations identified traits of both the class of chemical entities and the viral target that could help the design of novel, more potent molecules for the development of pan-bunyavirus antivirals.

Source: Antiviral Research

DOI: 10.1016/j.antiviral.2020.104947

Authors: Yaiza Fernández-García, Sebastiaan ter Horst, Marcella Bassetto, Andrea Brancale, Johan Neyts, Dominga Rogolino, Mario Sechi, Mauro Carcelli, Stephan Günther, Joana Rocha-Pereira

Institutions: Bernhard Nocht Institute for Tropical Medicine, Rega Institute for Medical Research, KU Leuven, Swansea University, Cardiff University, University of Parma, University of Sassari

Language: English

Topic: Viral Infections and Vectors

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,950

Funders: Dipartimenti di Eccellenza, University of Glasgow, Bundesministerium für Bildung und Forschung, Ministero dell’Istruzione, dell’Università e della Ricerca, KU Leuven, Medical Research Council

Awards: G1575657597, ORIGINALE CHEMIAE in Antiviral Strategy - Origin and Modernization of Multi-Component Chemistry as a Source of Innovative Broad Spectrum Antiviral Strategy, Screening zur Identifizierung antiviraler Wirkstoffe für die Behandlung von Hantavirus Infektionen

OpenAlex ID: W3088091771

FWCI: 0.852

Cites: 24

Cited by: 39

Related to: 10