Work

Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus

Year: 2020

Type: article

Abstract: The propensity of broad-spectrum antibiotics to indiscriminately kill both pathogenic and beneficial bacteria has a profound impact on the spread of resistance across multiple bacterial species. Alternative approaches that narrow antibacterial specificity towards desired pathogenic bacterial population are of great interest. Here, we report an enzyme-responsive antibiotic-loaded nanoassembly strategy for narrow delivery of otherwise broad-spectrum antibiotics. We specifically target Staphylococcus aureus (S. aureus), an important blood pathogen that secretes PC1 β-lactamases. Our nanoassemblies selectively eradicate S. aureus grown in vitro with other bacteria, highlighting its potential capability in targeting the desired pathogenic bacterial population.

Source: Nanoscale

DOI: 10.1039/d0nr04886k

Authors: Thameez M. Koyasseril-Yehiya, Alam García-Heredia, Francesca Anson, Poornima Rangadurai, M. Sloan Siegrist, S. Thayumanavan

Institutions: Amherst College, University of Massachusetts Amherst

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Universidad Autónoma de Nuevo León, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases