Effect of time of day of recreational and household physical activity on prostate and breast cancer risk ( MCC‐Spain study)
Year: 2020
Type: article
Study design: Observational Study
Abstract: Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10 am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.
Source: International Journal of Cancer
DOI: 10.1002/ijc.33310
Authors: Jakob Weitzer, Gemma Castaño‐Vinyals, Nuria Aragonés, Inés Gómez‐Acebo, Marcela Guevara, Pilar Amiano, Vicente Martín, Ana Molina‐Barceló, Juan Alguacil, Victor Moreno, Claudia Suarez‐Calleja, José Juan Jiménez‐Moleón, Rafael Marcos‐Gragera, Kyriaki Papantoniou, Beatriz Pérez‐Gómez, Javier Llorca, Nieves Ascunce, Leire Gil, Esther Gracia‐Lavedan, Delphine Casabonne, Virginia Lope, Marina Pollán, Manolis Kogevinas
Institutions: Universitat Pompeu Fabra, Medical University of Vienna, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital del Mar Research Institute, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Basque Government, Biogipuzkoa Health Research Institute, Universidad de León, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de Huelva, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Universitat de Girona, Institut d'Investigació Biomèdica de Girona, Instituto de Salud Carlos III, Centro Nacional de Epidemiología, GEICAM – Spanish Breast Cancer Group
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Centres de Recerca de Catalunya, European Commission, Ministerio de Economía y Competitividad, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Junta de Andalucía, Junta de Castilla y León, Fundación Marqués de Valdecilla, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III
OpenAlex ID: W3088464528