Work

Magnetic Liposomes for Remote Controlled High-Molecular Drugs Release under a Low-Frequency Non-Heating Magnetic Field

Year: 2020

Type: article

Abstract: Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that an increase of up to 35% of the protein release rate occurred when the MALip are exposed to the LF AMF (frequency 110 Hz, intensity 75–150 kA/m) for 5–15 min. The research provides prospects for the development of remotely controlled protein release from liposomes.

Source: Moscow University Chemistry Bulletin

DOI: 10.3103/s0027131420040112