African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. METHODS: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). RESULTS: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P = .03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. CONCLUSIONS: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.
Source: Cancer
DOI: 10.1002/cncr.33208
Authors: Talha Badar, Parameswaran Hari, Omar Dávila, Raphael Fraser, Baldeep Wirk, Binod Dhakal, Cesar O. Freytes, Cesar Rodriguez Valdes, Cindy Lee, David H. Vesole, Ehsan Malek, Gerhard C. Hildebrandt, Heather Landau, Hemant S. Murthy, Hillard M. Lazarus, Jesus G. Berdeja, Kenneth R. Meehan, Melhem Solh, Miguel Angel Diaz, Mohamed A. Kharfan‐Dabaja, Natalie S. Callander, Nosha Farhadfar, Qaiser Bashir, Rammurti T. Kamble, Ravi Vij, Reinhold Munker, Robert A. Kyle, Saurabh Chhabra, Shahrukh Hashmi, Siddhartha Ganguly, Sundar Jagannath, Taiga Nishihori, Yago Nieto, Shaji Kumar, Nina Shah, Anita D’Souza
Institutions: Medical College of Wisconsin, Penn State Cancer Institute, Penn State Milton S. Hershey Medical Center, Atrium Health Wake Forest Baptist, Royal Adelaide Hospital, Hackensack University Medical Center, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, University Hospitals Seidman Cancer Center, University of Kentucky, Markey Cancer Center, Memorial Sloan Kettering Cancer Center, Mayo Clinic in Florida, Mayo Clinic Comprehensive Cancer Center (Florida), Case Western Reserve University, Sarah Cannon, Dartmouth–Hitchcock Medical Center, Northside Hospital, Hospital Infantil Universitario Niño Jesús, University of Wisconsin–Madison, University of Wisconsin Carbone Cancer Center, University of Florida Health, University of Florida, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Washington University in St. Louis, Mayo Clinic, King Faisal Specialist Hospital & Research Centre, The University of Kansas Health System, Moffitt Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1244422278, Cost Effectiveness Analysis of Stem Cell Transplant in Older MDS Patients, G1387388519, Identifying Predictors of Poor Health-Related Quality-of-life among Pediatric Hematopoietic Stem Cell Donors, G1664930879, G1679149754, G2127529049, G2551907125, G2564302013, G2662898727, G3083416222, G3123660505, G3158753476, G345720138, G3540884004, G3699198379, G3745029439, G3888413642, G3922948135, G3928191929, G4135568677, G4334469717, G460283006, G4669804995, G4763906650, Cure Sickle Cell, G4867292856, G4898549738, G4904899903, G4905003149, G4910750673, G5039041663, G5079632146, G5186918478, G5233146051, G5236668762, G5356860631, G536687284, G5478485217, G563297368, G5636469388, G5735794559, G5804481516, G5843619112, G6078526581, G6079157135, G6238506038, G6463560129, G6659488911, G6793234220, G686564698, G6932420423, G6953855193, BMT Clinical Research Network Data Coordinating Center, G6979277618, G7121792964, G7135906342, G715986205, G7297870625, G7309481926, G7422851495, G746619137, G772836402, G7733677619, G7766946159, G7795396226, G7997008089, G8039400965, G8202316291, G8366129954, G8512811846, G8666848461, G8726426755, G8871973681, G8876996369, G8900316802, Cancer Center Support Grant, Molecular and Cellular Mechanisms of Chronic Myelomonocytic Leukemia (CMML), Immuno and Epigenetics of Hematopoietic Cell Transplantation, A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research, NK cells, their receptors and cancer therapy, Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc., Hematopoietic Stem Cell And Cord Blood Transplantation
OpenAlex ID: W3089242107