Genetic Polymorphisms in Fructokinase and Aldolase B, and Biomarkers of the Metabolic Syndrome
Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: In the absence of consistent clinical evidence, concerns have been raised regarding the potential role of fructose in the development of the Metabolic Syndrome (MetS). We determined whether common polymorphisms in the genes involved in fructose metabolism (Fructokinase (KHK), and Aldolase B (ALDOB)) modify the association between fructose intake and biomarkers of the MetS (waist circumference, blood pressure, triglyceride, HDL-cholesterol and blood glucose). Fructose intake was measured using a food frequency questionnaire and genotyping was completed using real-time PCR. We found no association between the KHK (rs2119026) and fructose intake or biomarkers of the MetS. The ALDOB (rs1929480) was associated with decreased HDL-cholesterol in East Asians, while the ALDOB (515313) modified the association between dietary fructose and serum triglyceride in South Asians. The results suggest that partial and incomplete metabolism of fructose in the liver may have adverse metabolic effects.
Source: TSpace (University of Toronto)
Author: Neshat Deljoomanesh
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3089244355