Work

Manipulation of host signalling for the characterisation and control of dengue fever

Year: 2020
Type: dissertation
Abstract: Dengue fever is a mosquito-transmitted disease of the tropics and sub-tropics that is caused by dengue virus (DENV).There are an estimated 60-100 million clinical cases of dengue fever per year, resulting in at least 10,000 deaths.Most clinical cases of dengue are characterised by flu-like symptoms.However, for unknown reasons, a small proportion (1-2%) of clinical cases progress to a life-threatening form of disease referred to as "severe dengue".Severe dengue is characterised by cytokine storms, heightened This page has intentionally been left blank v Declaration This is to certify that this thesis comprises only my original work, except where indicated in the preface.All the work detailed herein was performed following the commencement of my PhD
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W3089266549
Cites: 318
Cited by:
Related to: 10