Work

Reality CHEK: Understanding the biology and clinical potential of CHK1

Year: 2020

Type: review

Abstract: The DNA damage response enables cells to cope with various stresses that threaten genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 which is encoded by the CHEK1 gene. Originally identified as a regulator of the G2/M checkpoint, CHK1 has since been shown to play important roles in DNA replication, mitotic progression, DNA repair, and overall cell cycle regulation. However, the potential of CHK1 as a cancer therapy has not been realized clinically. Herein we expound our current understanding of the principal roles of CHK1 and highlight different avenues for CHK1 targeting in cancer therapy.

Source: Cancer Letters

DOI: 10.1016/j.canlet.2020.09.016

Authors: Fiifi Neizer-Ashun, Resham Bhattacharya

Institutions: University of Oklahoma Health Sciences Center, University of Oklahoma, OU Health Stephenson Cancer Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550