Bedside to bench Alport syndrome research: are human urine‐derived podocytes the answer? †
Year: 2020
Type: article
Abstract: In a recent issue of The Journal of Pathology, Iampietro et al isolated and characterized several clones of urine-derived podocytes from three patients with Alport syndrome (AS) and proteinuria and one age-matched non-proteinuric control. They reported differential expression of genes involved in cell motility, adhesion, survival, and angiogenesis. The authors found AS podocytes to be less motile and to have significantly higher permeability to albumin compared to control podocytes, highlighting that AS podocytes may retain their phenotype even when losing contact with the glomerular basement membrane. The establishment of urine-derived podocyte cell lines from patients with different genetic forms of AS may represent a valuable and minimally invasive tool to investigate the cellular mechanisms contributing to kidney disease progression in AS and may allow for the establishment of patient-specific drug screening opportunities. © 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Source: The Journal of Pathology
DOI: 10.1002/path.5564
Authors: Jin‐Ju Kim, Alessia Fornoni
Institution: University of Miami
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: F. Hoffmann-La Roche, Center for Strategic Scientific Initiatives, National Cancer Institute, Alport Syndrome Foundation, National Institutes of Health, Miami Clinical and Translational Science Institute, University of Miami, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1023762287, G242051987, G3258811144, G4181306107, G4341361184, The role of DDR1 in podocyte lipotoxicity and progression of Alport Syndrome, SMPDL3b and podocyte insulin signaling in DKD, G6080841962, Miami Clinical and Translational Science Institute, G7241994140, 1-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center
OpenAlex ID: W3089704145