Work

LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development

Year: 2020

Type: article

Abstract: homologue Lasp from a subset of commissural neurons in the developing ventral nerve cord produces defasciculated axon bundles that do not reach their targets. Together, our data support a novel role for LASP1 in actin-based lamellipodial protrusion and establish LASP1 as a positive regulator of both in vitro and in vivo axon development.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e20-06-0366

Authors: Stephanie L. Pollitt, Kenneth R. Myers, Jin Yoo, James Q. Zheng

Institution: Emory University

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: G436868585, G5722520638, G6701430781, G8793770017