Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: High-frequency jet ventilation (HFJV) is primarily used in premature neonates; however, its use in pediatric patients with acute respiratory failure has been reported. The objective of this study was to evaluate HFJV use in the pediatric critical care setting. We hypothesized that HFJV would be associated with improvements in oxygenation and ventilation. METHODS: Medical records of all patients who received HFJV in the pediatric ICU of a quaternary care center between 2014 and 2018 were retrospectively reviewed. Premature infants who had not been discharged home were excluded, as were those in whom HFJV was started while on extracorporeal membrane oxygenation. Data on demographics, pulmonary mechanics, gas exchange, and outcomes were extracted and analyzed using chi-square testing for categorical variables, nonparametric testing for continuous variables, and a linear effects model to evaluate gas exchange over time. RESULTS: A total of 35 subjects (median age = 2.9 months, median weight = 5.2 kg) were included. Prior to HFJV initiation, median (interquartile range) oxygenation index (OI) was 11.3 (7.2–16.9), P aO 2 /F IO 2 = 133 (91.3–190.0), pH = 7.18 (7.11–7.27), P aCO 2 = 64 (52–87) mm Hg, and P aO 2 = 74 (64–125) mm Hg. For subjects still on HFJV ( n = 25), there was no significant change in OI, P aO 2 /F IO 2 , or P aO 2 at 4–6 h after initiation, whereas pH increased ( P = .001) and P aCO 2 decreased ( P = .001). For those remaining on HFJV for > 72 h ( n = 12), the linear effects model revealed no differences over 72 h for OI, P aO 2 /F
Source: Respiratory Care
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3089965928