Work

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

Year: 2020

Type: article

Abstract: Five new [daphneodorins D–H ( 1, 5, and 10 – 12 )] and seven known daphnane diterpenoids ( 2 – 4 and 6 – 9 ) were isolated from Daphne odora . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters ( 1 – 9 ) showed potent anti-HIV activity with EC 50 values of 1.5–7.7 nM.

Source: Journal of Natural Products

DOI: 10.1021/acs.jnatprod.0c00540

Authors: Kouharu Otsuki, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, Kazuo Koike

Institutions: Toho University, Duke Medical Center, University of North Carolina at Chapel Hill, China Medical University, China Medical University Hospital

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science, National Institute of Allergy and Infectious Diseases

Awards: G357329590, G3813997721, G3827253311, Plant Anti-HIV Agents, Phytochemical investigation of Daphnane-type diterpenoids aiming to discover next generation anti-HIV drugs, Study on bioactive diterpenoids from medicinal plants of Thymelaeaceae and Euphorbiaceae families

OpenAlex ID: W3090599442

FWCI: 1.299

Cites: 22

Cited by: 31

Related to: 10