Circulating 25-Hydroxyvitamin D and the Risk of Rarer Cancers: Design and Methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
Year: 2010
Type: article
Abstract: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-<75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwq116
Authors: L. Gallicchio, K. J. Helzlsouer, W.-H. Chow, D. M. Freedman, S. E. Hankinson, P. Hartge, V. Hartmuller, C. Harvey, R. B. Hayes, R. L. Horst, K. L. Koenig, L. N. Kolonel, F. Laden, M. L. McCullough, D. Parisi, M. P. Purdue, X.-O. Shu, K. Snyder, R. Z. Stolzenberg-Solomon, S. S. Tworoger, A. Varanasi, J. Virtamo, L. R. Wilkens, Y.-B. Xiang, K. Yu, A. Zeleniuch-Jacquotte, W. Zheng, C. C. Abnet, D. Albanes, K. Bertrand, S. J. Weinstein
Institution: Mercy Medical Center
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,856
Funders: New York City Department of Health and Mental Hygiene, Brigham and Women's Hospital, Purdue University, Vanderbilt University, Maryland Department of Health and Mental Hygiene, Vanderbilt-Ingram Cancer Center, Johns Hopkins University, York University, National Institutes of Health, National Institute of Standards and Technology, School of Medicine, New York University, School of Medicine, Vanderbilt University, Johns Hopkins Bloomberg School of Public Health, National Institute on Aging, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Awards: PROSTATE, LUNG, COLORECTAL &OVARIAN (PLCO) CANCER, G1111060425, G1129713815, PROSTATE, LUNG, COLORECTAL AND OVARIAN CANCER, PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, G1267016694, G1285883624, G142049768, G1578565442, DNA Repair, Skin Cancer and Overall Cancer Risk, PROSTATE, LUNG, COLORECTAL, AND OVARIAN (PLCO) CANCER, PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, G2022468402, G2070044820, G216524704, G2250436683, PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, Biochemical Markers in the nurses' Health Study Cohort, FOLLOW-UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY , PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, PROSTATE, LUNG, COLORECTAL, &OVARIAN CANCER SCREENING, Cancer Risk Reduction and Diet: A Cohort Study of Women, PROSTATE, LUNG, COLORECTAL &OVARIAN CANCER, PROSTATE, LUNG, COLORECTAL AND OVARIAN CANCER, G3166288362, G3205575695, G3446191057, U S-FINLAND STUDIES OF NUTRITION AND CANCER, G361298724, Multiethnic Cohort Study of Diet and Cancer, Molecular Pathoepidemiology of Endometrial Cancer Risk, WS No. 12 Patterns of Care DX Year 2008, Dietary and Hormonal Determinants of Cancer in Women, G3986927127, G4014730521, Vitamin D, Related Genes and Breast Cancer Risk, PREVENTIVE ONCOLOGY ACADEMIC AWARD, PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER, G459566519, G4922896994, G5198629111, Cohort Study of Cancer-Inhibitory Dietary Factors in Men, Genetic Susceptibility to Cancer in Multiethnic Cohorts, G6124801312, G6219625355, G6375054419, G667355291, G668214460, GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT, Prospective Studies of Diet and Cancer in Men and Women, G7238814555, G7400349024, G7421337856, G7442572985, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, G8312728332, G840131496, G8509316824, G914455950, G957887912, G979407967, G996329585
OpenAlex ID: W2102106688