Year: 2020
Type: article
Abstract: Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable reestablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de- and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.
Source: Nature Communications
Institutions: German Center for Neurodegenerative Diseases, Institut für Klinische Neuroimmunologie, German Center for Neurodegenerative Diseases (DZNE) Dresden, Technical University of Munich, Ludwig-Maximilians-Universität München, Munich Cluster for Systems Neurology, Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut du Cerveau
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,628
Awards: G1202780504, MyelinRemodeling in vivo: Eine Längsschnittstudie zur gezielten Myelinisierung und neuronalen Kontrolle der spärlichen Myelinisierung in der Mausrinde, G1636457746, G1789099517, G1817951634, G192932977, G1993314343, Mechanisms of Developmental and Injury-related Axon Branch Loss, G2319897897, G2830669520, Neuroprotection in Multiple Sclerosis: From Molecular Imaging to Screenable Models, G3128737150, G3207356259, G3401491360, G3430239858, EXC 2145: Munich Cluster for Systems Neurology (SyNergy), G4117365907, G431947728, G434337789, G4940844746, Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity, G5527200290, G5537318980, G5986966232, G668267130, G7169966579, Infrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciences, BREaking the COde of MYelination, G7588833808, G77488120, G7950531811, TRR 274: Kontrollpunkte der ZNS Reparatur, G896728979, G997581502
OpenAlex ID: W3091095424