Work

Access to α-Pyrazole and α-Triazole Derivatives of Ketones from Oxidative Heteroarylation of Silyl Enolethers

Year: 2020

Type: article

Abstract: The synthesis of α-pyrazole and α-triazole derivatives of ketones by the ceric ammonium nitrate-mediated oxidative coupling of enolsilanes with heteroarenes is reported. The reaction proceeds under mild reaction conditions to provide a diversity of products, including sterically hindered fully substituted derivatives.

Source: Organic Letters

DOI: 10.1021/acs.orglett.0c03005

Authors: Sandeep Dhanju, Aidan C. Caravana, Regan J. Thomson

Institution: Northwestern University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G1969565822, New Methods and Strategies for the Concise Synthesis of Bioactive Polycyclic Molecules, G3862198234