Methamphetamine administration dose effects on sexual desire, sexual decision making, and delay discounting.
Year: 2020
Type: article
Abstract: = 19) participated in this within-subject, placebo-controlled study comparing the effects of 0 mg, 20 mg, and 40 mg of oral methamphetamine. Compared to placebo, methamphetamine caused dose-related and time-related increases in a single-item sexual desire rating and some standard stimulant abuse liability ratings, as well as dose-related increases in the Sexual Arousal and Desire Inventory (SADI; a multidimensional scale capturing positive and negative aspects of desire/arousal). However, methamphetamine caused no significant mean differences in likelihood of condom use within the Sexual Delay Discounting Task or the Monetary Discounting Task. SADI scores were negatively correlated with change from placebo in condom use likelihood in the Sexual Delay Discounting Task for some partner conditions (i.e., decreased reported likelihood of condom use in participants who experienced increased desire/arousal and vice versa). These mixed results may be consistent with methamphetamine's role as both a treatment for attention-deficit/hyperactivity disorder and as a drug of abuse associated with increased delay discounting, and they suggest that methamphetamine's effects on discounting may be modulated by the reinforcing properties of what is being discounted. Delay discounting may be an understudied element of risky sexual decision making, particularly among individuals who use methamphetamine. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
DOI: 10.1037/pha0000398
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Funder: National Institute on Drug Abuse
Awards: HIV Sexual Risk Behavior: Methamphetamine and Delay Discounting of Sexual Rewards, G4789306762, Role of delay discounting in driving HIV sexual risk behavior in cocaine abuse, G8364713034, Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination, Human Behavioral Pharmacology of Substance Abuse
OpenAlex ID: W3091468177