Emerging roles of the TRPV4 channel in bladder physiology and dysfunction
Year: 2020
Type: review
Abstract: The transient receptor potential vanilloid type 4, TRPV4, is a polymodal cation channel which can be activated by diverse stimuli including mechanical, thermal and chemical cues. In the urinary bladder, TRPV4 is not only abundantly expressed in the urothelium but may also be localized in subepithelium, detrusor smooth muscles and afferent neurons. Emerging evidence indicates that the TRPV4 channel plays a sensory role in the uroepithelium, where it may regulate the release of sensory mediators such as ATP, which in turn modulates afferent nerve activity in response to bladder filling during the urination cycle. TRPV4 may also directly regulate detrusor contractility and the urothelial barrier function. Altered TRPV4 expression has been detected in various pathological bladder conditions. As such, TRPV4 may be a promising therapeutic target for bladder dysfunctions.
Source: The Journal of Physiology
DOI: 10.1113/jp279776
Authors: Yanyuan Wu, Jun Qi, Changhao Wu, Weifang Rong
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G2100174335, G3906452707, G50596728, Mode of action of sensory transmitters in bladder urothelium and the effect of ageing, G5477785924, G5745286343, Nox Enzymes in Aging Bladder Dysfunction, NIA CO-FUNDING SCHEME: Nox enzymes in aging bladder dysfunction, Surrey and Shanghai Jiao Tong partnership on visceral organ sensory research during ageing
OpenAlex ID: W3091937797