Work

Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/β-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway.

Year: 2020

Type: article

Abstract: . Mechanically, lycorine reduced the protein level of β-catenin and its' downstream molecule c-Myc. Furthermore, lycorine also decreased the phosphorylation of ERK1/2 and AKT. Together, our results reveal that lycorine may inhibit tumor growth of OS cells possibly through suppressing Wnt/β-catenin, ERK1/2 and PI3K/AKT signaling pathway.

Source: PubMed Central

Authors: Xiao-Hui Yuan, Ping Zhang, Ting-Ting Yu, Hua-Kun Huang, Lu-Lu Zhang, Chun-Mei Yang, Tao Tan, Sheng-Dong Yang, Xiao-Ji Luo, Jin-Yong Luo

Institutions: Chongqing Medical University, The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3091949755

FWCI: 0.873

Cites: 50

Cited by: 21

Related to: 10