Work

The role of insulin-like growth factors and epidermal growth factor-related peptides in intraovarianregulation in the pig ovary

Year: 2020

Type: article

Abstract: The autocrine and paracrine role of the insulin-like growth factors (IGFs) and epiderrnal growth factor (EGF)-related peptides in pig ovary are reviewed.For convenience, each of these regulatory systems is divided into several interactive components: regulated expression of the growth factors, growth factor reception at the cell surface and intracellular action of the growth factors.In addition, the concept of regulated bioavailability and targeting of growth factors in the extracellular space is developed as an important control locus and area for future study.With regard to the 1GF system, these components include two ligands -IGF-1 and -II, both expressed in the porcine ovary -and the possibility of three receptors.IGF-I and the

Source: Bioscientifica Proceedings

DOI: 10.1530/biosciprocs.14.008