Work

ASK1 inhibits proliferation and migration of lung cancer cells via inactivating TAZ.

Year: 2020

Type: article

Abstract: . It seems that ASK1 specifically inactivates TAZ, not YAP, as ASK1 blocked nuclear translocation of TAZ only, while had no effect on YAP. Furthermore, knockdown of TAZ in the lung cancer cells caused the same inhibitory effect on cell proliferation and migration as that of overexpression of ASK1. Thus, our studies have defined a new signaling pathway of ASK1 for regulation of lung cancer cell proliferation and migration via interacting with and inactivating TAZ.

Source: PubMed

Authors: Tiantian Han, Jinyi Gao, Lincui Wang, Yaping Qu, Aiqin Sun, Ke Peng, Jun Zhu, Hanqing Liu, Wannian Yang, Genbao Shao, Qiong Lin

Institution: Jiangsu University

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3092032884

FWCI: 1.269

Cites: 35

Cited by: 19

Related to: 10