Work

HMGB1-induced autophagy promotes extracellular matrix degradation leading to intervertebral disc degeneration.

Year: 2020

Type: article

Abstract: <0.05). Therefore, we concluded that HMGB1 was up-regulated in IDD and HMGB1-induced autophagy can promotes extracellular matrix degradation and thus lead to intervertebral disc degeneration. In brief, HMGB1 may serve as a novel diagnostic biomarker and therapeutic target for IDD.

Source: PubMed

Authors: Biao Fu, Xia Lu, Er-Yang Zhao, Ji-Xin Wang, Si-Min Peng

Language: English

Topic: Spine and Intervertebral Disc Pathology

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3092095451

FWCI: 1.197

Cites: 27

Cited by: 8

Related to: 10