Comparison of Parental Report of Influenza Vaccination to Documented Records in Children Hospitalized With Acute Respiratory Illness, 2015–2016
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Parent-reported influenza vaccination history may be valuable clinically and in influenza vaccine effectiveness (VE) studies. Few studies have assessed the validity of parental report among hospitalized children. METHODS: Parents of 2597 hospitalized children 6 months-17 years old were interviewed from November 1, 2015 to June 30, 2016, regarding their child's sociodemographic and influenza vaccination history. Parent-reported 2015-2016 influenza vaccination history was compared with documented vaccination records (considered the gold standard for analysis) obtained from medical records, immunization information systems, and providers. Multivariable logistic regression analyses were conducted to determine potential factors associated with discordance between the 2 sources of vaccination history. Using a test-negative design, we estimated VE using vaccination history obtained through parental report and documented records. RESULTS: According to parental report, 1718 (66%) children received the 2015-2016 influenza vaccine, and of those, 1432 (83%) had documentation of vaccine receipt. Percent agreement was 87%, with a sensitivity of 96% (95% confidence interval [CI], 95%-97%) and a specificity of 74% (95% CI, 72%-77%). In the multivariable logistic regression, study site and child's age 5-8 years were significant predictors of discordance. Adjusted VE among children who received ≥1 dose of the 2015-2016 influenza vaccine per parental report was 61% (95% CI, 43%-74%), whereas VE using documented records was 55% (95% CI, 33%-69%). CONCLUSIONS: Parental report of influenza vaccination was sensitive but not as specific compared with documented records. However, VE against influenza-associated hospitalizations using either source of vaccination history did not differ substantially. Parental report is valuable for timely influenza VE studies.
Authors: Constance E Ogokeh, Angela P Campbell, Leora R Feldstein, Geoffrey A Weinberg, Mary A Staat, Monica M McNeal, Rangaraj Selvarangan, Natasha B Halasa, Janet A Englund, Julie A Boom, Parvin H Azimi, Peter G Szilagyi, Christopher J Harrison, John V Williams, Eileen J Klein, Laura S Stewart, Leila C Sahni, Monica N Singer, Joana Y Lively, Daniel C Payne, Manish Patel, New Vaccine Surveillance Network
Institutions: Centers for Disease Control and Prevention, Oak Ridge Institute for Science and Education, University of Rochester Medicine, University of Rochester, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Children's Mercy Hospital, University of Missouri–Kansas City, Vanderbilt University Medical Center, University of Washington, Seattle Children's Research Institute, Baylor College of Medicine, Texas Children's Hospital, University of California, San Francisco, UCSF Benioff Children's Hospital, University of California, Los Angeles, Mattel Children's Hospital, University of Pittsburgh
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,752
Awards: G2181888443, IP21-002, ENHANCED SURVEILLANCE NETWORK FOR ENTERIC AND RESPIRATORY VIRUSES IN CHILDREN: ASSESSING DISEASE BURDEN, NATURAL HISTORY, AND VACCINE EFFECTIVENESS, ENHANCED SURVEILLANCE FOR NEWLY PREVENTABLE DISEASES (ARI AND AGE SURVEILLANCE) ROCHESTER, NY, G7543494365, ENHANCED SURVEILLANCE FOR NEW VACCINE PREVENTABLE DISEASES, ENHANCED SURVEILLANCE FOR NEW VACCINE PREVENTABLE DISEASES, ENHANCED SURVEILLANCE FOR NEW VACCINE PREVENTABLE DISEASES
OpenAlex ID: W3092095843