Work

Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite

Year: 2020

Type: article

Abstract: Host cell invasion by the malaria parasite is critical for establishing infection in human host and is dependent on discharge of key ligands from organelles like rhoptry and microneme, and these ligands interact with host RBC receptors. In the present study, we demonstrate that phosphorylation of a key rhoptry protein, RhopH3, is critical for host invasion. Phosphorylation regulates its localization to rhoptries and discharge from the parasite.

Source: mBio

DOI: 10.1128/mbio.00166-20

Authors: Roseleen Ekka, Ankit Gupta, Sonika Bhatnagar, Pawan Malhotra, Pushkar Sharma

Institutions: National Institute of Immunology, International Centre for Genetic Engineering and Biotechnology

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900