Work

Candida glabrata Yap6 Recruits Med2 To Alter Glycerophospholipid Composition and Develop Acid pH Stress Resistance

Year: 2020

Type: article

Abstract: This study investigated the function of the Mediator tail subunit Cg Med2 in C. glabrata under low-pH stress. The protein kinase Cg Yak1 activates Cg Yap6 for the recruitment of Cg Med2, which in turn increases glycerophospholipid content and membrane integrity to confer low-pH stress tolerance. This study establishes a new link between the Mediator tail subunit and transcription factors. Overall, these findings indicate that Cg Med2 is a novel target to induce the low-pH stress response in C. glabrata .

Source: Applied and Environmental Microbiology

DOI: 10.1128/aem.01915-20

Authors: Pei Zhou, Xiaoke Yuan, Hui Liu, Yanli Qi, Xiulai Chen, Liming Liu

Institutions: Jiangnan University, State Key Laboratory of Food Science and Technology

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities

Awards: G7507917606, 苹果酸合成路径的碳流封存调控及其机制解析, G8645330278