Work

Pallidothalamic tract activation predicts suppression of stimulation-induced dyskinesias in a case study of Parkinson’s disease

Year: 2020

Type: article

Abstract: One of the potential side-effects of deep brain stimulation (DBS) in the subthalamic nucleus (STN) in individuals with Parkinson’s disease is dyskinesia which cannot be relieved by reducing the dosage of levodopa [1]. Previous studies reported that stimulation in the area dorsal to STN arrests stimulation-induced dyskinesia [2,3] and can also reduce levodopa-induced dyskinesia [4,5]. This region dorsal to STN contains a rich collection of ascending and descending fiber pathways including axons from cells in the globus pallidus internus (GPi) that project through the lenticular fasciculus and thalamic fasciculus en route to the thalamus and brainstem.

Source: Brain stimulation

DOI: 10.1016/j.brs.2020.09.022