Year: 2020
Type: article
Abstract: Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease.The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.To adapt to its environment and persist in each phase of its enzootic cycle, B. burgdorferi wields three systems to regulate the expression of genes: the RpoN-RpoS alternative sigma (σ) factor cascade, the Hk1/Rrp1 twocomponent system and its product c-di-GMP, and the stringent response mediated by RelBbu and DksA.These regulatory systems respond to enzootic phase-specific signals and are controlled or finetuned by transcription factors, including BosR and BadR, as well as small RNAs, including DsrABb and Bb6S RNA.In addition, several other DNA-binding and RNA-binding proteins have been identified, although their functions have not all been defined.Global changes in gene expression revealed by highthroughput transcriptomic studies have elucidated various regulons, albeit technical obstacles have mostly limited this experimental approach to cultivated spirochetes.Regardless, we know that the spirochete, which carries a relatively small genome, regulates the expression of a considerable number of genes required for the transitions between the tick vector and the vertebrate host as well as the adaptation to each.
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,654
Awards: Borrelia burgdorferi oligopeptide (Opp) transporter control of cellular homeostasis and growth, Post-transcriptional regulation in Borrelia burgdorferi by the BpuR RNA-binding protein, Regulation of glycerol utilization in Borrelia burgdorferi, Essential role of Hk1/Rrp1 TCS for survival of Borrelia burgdorferi in ticks, Virulence-associated genes in the Lyme disease spirochete, Metabolic regulation during the two-host lifecycle of Borrelia, RpoS Regulation of Borrelia burgdorferi Genes in vivo, SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes, Identification of genes required by Leptospira interrogans for mammalian host adaptation and/or persistence in the rat model, Regulation of gene expression in Borrelia burgdorferi, Regulation of infection-associated protein expressed by the Lyme disease spirochete DnaA protein, Regulatory Network of the Lyme Disease Pathogen
OpenAlex ID: W3092598393