Work

Signaling pathways involved in environmental sensing in Trypanosoma cruzi

Year: 2020

Type: review

Abstract: Trypanosoma cruzi is a unicellular parasite and the etiologic agent of Chagas disease. The parasite has a digenetic life cycle alternating between mammalian and insect hosts, where it faces a variety of environmental conditions to which it must adapt in order to survive. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Major environmental changes include temperature, nutrient availability, ionic composition, pH, osmolarity, oxidative stress, contact with host cells and tissues, host immune response, and intracellular life. Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and will be the subject of this review.

Source: Molecular Microbiology

DOI: 10.1111/mmi.14621

Authors: Noelia Lander, Miguel A. Chiurillo, Roberto Docampo

Institution: University of Georgia

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1892258141, Drug Target Validation in Trypanosoma cruzi, G5316311330, Calcium signaling in Trypanosoma brucei, Large-scale CRISPR screening of essential calcium-related genes in the human parasite Trypanosoma cruzi