Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.
Year: 2020
Type: article
Abstract: and translocation to nuclei. Knockdown of YAP by shRNAs produced a similar effect on proliferation and migration of gastric cancer AGS cells to that of GGylation inhibition, suggesting that GGylation signaling promotes gastric cancer cell proliferation and migration by activation of YAP. Our studies provide a potential new therapeutic targeting pathway for gastric cancer.
Source: PubMed
Authors: Jing Wei, Ke Peng, Jun Zhu, Lincui Wang, Tiantian Han, Aiqin Sun, Genbao Shao, Hanqing Liu, Wannian Yang, Qiong Lin
Institution: Jiangsu University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3092638846