Work

Chaiqi decoction ameliorates vascular endothelial injury in metabolic syndrome by upregulating autophagy.

Year: 2020

Type: article

Abstract: OBJECTIVE: The present study aimed to investigate the protective effect of the Chaiqi decoction on vascular endothelial injury in metabolic syndrome and to determine whether the underlying mechanism was associated with autophagy. METHODS: by transfecting cells with GFP-mRFP-LC3 adenoviruses or incubating with DALGreen and DAPRed. RESULTS: The metabolic syndrome model rats displayed adiposity, hyperglycemia, dyslipidemia, hypertension, thickened intima, deposition of various forms of collagen and lipid droplets, downregulated levels of phosphorylated endothelial nitric oxide synthase and nitric oxide, upregulated expression of endothelin 1, and dysfunctional autophagy. All these abnormalities were ameliorated by administration of the Chaiqi decoction to the metabolic syndrome rats. Furthermore, the Chaiqi-containing serum could upregulate autophagy similarly to rapamycin, in a time-dependent manner. CONCLUSION: The Chaiqi decoction could ameliorate vascular endothelial injury by improving autophagy in metabolic syndrome.

Source: PubMed

Authors: Xun Chen, Xiao-Ru Yan, Jing Liu, Li-Ping Zhang

Institutions: Beijing University of Chinese Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Guang’anmen Hospital

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3092648810

FWCI: 0.444

Cites: 80

Cited by: 8

Related to: 10