Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses
Year: 2020
Type: article
Abstract: The emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is causing global health and economic crises. Infants and children can be infected, but are less likely to develop severe abnormalities including neurological disorders compared with adults. However, whether SARS-CoV-2 can directly cause neurological impairments in pediatric patients is not known. The possible evolutionary and molecular relationship between SARS-CoV-2 and non-segmented RNA viruses were examined with reference to neurological disorders in pediatric patients. SARS-CoV-2 appears to share similar functional domains and protein sequences with neuroinvasive and neurotropic RNA viruses and thus has the potential to cause neurological diseases in pediatric patients.
Source: Journal of NeuroVirology
Author: Xiaodi Chen
Institutions: Brown University, Women & Infants Hospital of Rhode Island
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3092718306