Nutritional programming effects of probiotic lactobacilli on bone health in CD-1 Elite mice
Year: 2018
Type: dissertation
Abstract: Recent investigations have demonstrated that probiotics beneficially improve bone structure in adult rodent models. The aim of this study was to investigate if maternal administration of the probiotic mixture Lacidofil® (Lactobacillus rhamnosus R0011 and L. helveticus R0052) since conception beneficially programs bone health of 2 month old offspring. Female CD-1 mice received either Lacidofil® or sterile water throughout pregnancy and lactation. At weaning, offspring were randomized to stay on their mother’s respective treatment of switched to the opposite diet until age 2 months. Offspring receiving probiotics since conception had higher fecal levels of the R0011 strain. Maternal administration of Lacidofil® improved trabecular bone microarchitecture at the proximal tibia in male but not female offspring and cortical bone microarchitecture at the midpoint tibia in both sexes. Therefore, probiotic interventions targeting mothers during pregnancy and lactation may beneficially program the infant microbiome and bone health into young adulthood.
Source: TSpace (University of Toronto)
Author: Sara Stinson
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3092724769