Work

Multi-Level Regulation of Opioid-Induced Respiratory Depression

Year: 2020

Type: article

Abstract: Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.

Source: Physiology

DOI: 10.1152/physiol.00015.2020

Authors: Barbara Palkovic, Vitaliy Marchenko, Edward J. Zuperku, Eckehard A. E. Stuth, Astrid G. Stucke

Institutions: Medical College of Wisconsin, University of Osijek, Milwaukee VA Medical Center, Children's Hospital of Wisconsin

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences