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Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations

Year: 2020

Type: article

Abstract: The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.

Source: Physiology

DOI: 10.1152/physiol.00016.2020

Authors: Cory W. Baumann, Dongmin Kwak, LaDora V. Thompson

Institutions: Ohio University, Boston University, Hanyang University

Language: English

Topic: Frailty in Older Adults

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging